plusonePLUS NEW JOURNALCoVolume1 Issue1MultidisciplinaryEnglishmarch,2022NNY20230424Article Review Antimicrobial and antitubercular activity of novel pyrazole-4-carboxamide derivatives: Synthesis and characterizationEnglishY12shrutiauthorEnglishNsonamauthorEnglishY10.32677/yjm.v1i1.3271The current research aims to identify the newest class of antifungal, antibacterial, and antitubercular lead compounds. Through the use of a carboxamide linkage, recent research has designed and synthesized a unique class of pyrazole-based molecular hybrids of aryl amines. Using a multistep method, the desired pyrazole carboxamide derivative was prepared. Compounds were characterized using 1HNMR, C13 NMR, and MASS spectral techniques. These substances were tested for their ability as antibacterial, antifungal, and antitubercular agents. All the compounds tested against Gram-positive and Gram-negative pathogens and fungal strains showed good antibacterial activity. Against Gram-positive pathogens, compound 5i showed potent activity, compound 5k demonstrated potent activity against Gram-negative strains, and compounds 5a, 5i, and 5j established potent activity against fungal strains and the Mycobacterium tuberculosis H37Rv strain.Englishkey2https://plusone.ubipayroll.com/abstract?id=2References1619Abad-Garcand;iacute;a B, Garmand;oacute;n-Lobato S, Sand;aacute;nchez-Iland;aacute;rduya MB, Berrueta LA, Gallo B, Vicente F, Alonso-Salces RM. Polyphenolic contents in Citrus fruit juices: authenticity assessment. Eur Food Res Technol, 2014; 238:803-18.and;nbsp;https://doi.org/10.1007/s00217-014-2160-9Abotaleb M, Samuel SM, Varghese E, Varghese S, Kubatka P, Liskova A, Band;uuml;sselberg D. Flavonoids in cancer and apoptosis. Cancers, 2019; 11(1):28.and;nbsp;https://doi.org/10.3390/cancers11010028Amrutha K, Nanjan P, Shaji SK, Sunilkumar D, Subhalakshmi K, Rajakrishna L, Banerji A. Discovery of lesser-known flavones as inhibitors of NF-and;kappa;B signaling in MDA-MB-231 breast cancer cells-A SAR study. Bioorg Med Chem Lett, 2014; 24:4735-42.and;nbsp;https://doi.org/10.1016/j.bmcl.2014.07.093Androutsopoulos VP, Mahale S, Arroo RR, Potter G. Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. Oncol Rep, 2009a; 21(6):1525-8.and;nbsp;https://doi.org/10.3892/or_00000384